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Neurologic Stem CellProtocols

Regenerative Medicine for Neurologic Disorders

NEUROLOGIC

The Role of Stem Cell Clinical Research & Deployment
- Neurologic Disorders -

The Clero Stem Cell Treatment Center offers protocols and investigational use of Autologous Adult Adipose Derived Stem Cells (ADSC’s) for clinical research and deployment for numerous neurologic disorders, inclusive of:

Stroke Parkinson’s Disease Cognitive Impairment Peripheral Neuropathy Multiple Sclerosis Muscular Dystrophy

At Clero Stem Cell Treatment Center we exploit anti-inflammatory, immuno-modulatory and regenerative properties of adult stem cells to mitigate inflammatory and degenerative diseases. These ADSC’s cells are derived from fat – an exceptionally abundant source of stem cells – that has been removed during our mini-liposuction office procedure. The source of the regenerative stem cells actually comes from stromal vascular fraction (SVF) – a protein rich segment from processed adipose tissue. Stromal vascular fraction contains a mononuclear cell line (predominantly autologous mesenchymal stem cells), macrophage cells, endothelial cells, red blood cells, and important growth factors that facilitate the stem cell process and promote their activity. Our technology allows us to isolate high numbers of viable cells that we can deploy during the same surgical setting.

The SVF – stem cell fraction are deployed back into the patient’s body via injection or IV infusion on an outpatient basis; the total procedure takes less than two hours. Not all neurologic disorders respond to stem cell therapy, and each patient must be assessed individually to determine the potential for optimal results from this regenerative medicine process.

The Clero Stem Cell Treatment Center is committed not only to providing a high degree of quality care for our patients – but we are also highly committed to clinical stem cell research and the advancement of regenerative medicine. At the Clero Stem Cell Treatment Center we exploit anti-inflammatory, immuno- modulatory and regenerative properties of adult stem cells to mitigate inflammatory and degenerative diseases.




Stroke

In the United States, approximately 800,000 Strokes occur each year; 1 stroke occurrs every 40 seconds, and taking 1 life approximately every 4 minutes, according to the American Heart Association / American Stroke Association. Nearly 75% of all strokes occur in people over the age of 65. The risk of having a stroke more than doubles each decade after the age of 55.

World wide, according to the World Health Organization (WHO) – Stroke is the number 1 cause of Disability; the number 2 cause of Dementia, and the number 3 cause of Death. Also, according to the WHO, 15 million people suffer stroke worldwide each year. Of these, 5 million die, and another 5 million are permanently disabled.

According to the National Institute of Neurological Disorders and Strokes (USA), Stroke is the 3rd leading cause of death and the leading cause of long-term disability in the U.S. There are approximately 4 million Americans living with the effects of stroke.

In the United States alone there are an estimated 7,000,000 stroke survivors in the U.S. over the age of 20.

Two million (2,000,000) brain cells die every 1 minute during stroke, increasing risk of permanent brain damage, disability or death. The prevalence of transient ischemic attacks (TIA – “mini strokes”) increases with age. Up to 40% of all people who suffer a TIA will go on to experience a stroke. The estimated direct and indirect cost of stroke in the United States in 2010 is $73.7 billion.

Stroke is also known as Cerebro-vascular Accident (CVA). Stroke can be caused by a disturbance in blood supply to the brain – this is often called an Ischemic Stroke. Because there is decreased blood supply, that part of the brain will suffer from lack of oxygen and, as a result, there will be vital tissue (brain) death and destruction. The second type of CVA is called a “hemorrhagic stroke” which occurs when there is a burst of a blood vessel within the brain.

Symptoms vary depending on the anatomic location of the ischemic event and extent and duration of the tissue loss. Common symptoms of stroke damage include impairments in speech, movement, sensation, and other functions most of us take for granted.





Stroke Recovery & Rehabilitation & the Clero Stem Cell Treatment Center

Stroke management generally includes control and limitation of swelling, edema, inflammation and neovascularization of damaged tissue. After a few months of therapy and rehabilitation, patients are usually told that further progress is unlikely.

Regenerative medicine research, however, suggests that improvements can be made months, even years after a stroke. Indeed, stroke management involves long term healing – even as long as to 12 to 18 months after a CVA. Researchers particularly in Europe have been actively studying the use of mesenchymal stem cells to help promote healing after ischemic brain injury from stroke.

The Clero Stem Cell Treatment Center offers a protocol for stroke damage that utilizes the beneficial properties of adult stem cells. The Clero Stem Cell Treatment Center employs specially developed specific SVF deployment protocol that attempts to utilize the anti inflammatory and potential regenerative properties of SVF (rich in mesenchymal stem cells and growth factors). SVF is systemically deployed and is expected to focus on damaged areas of the central nervous system. Special measures are taken to optimize transport of the SVF across the blood-brain barrier to improve central nervous system uptake. During an outpatient process, the patient’s own stem cells are derived from adipose (fat) tissue – the richest source of adult stem cells–which are harvested by our surgeon during a mini- liposuction under local anesthesia. This regenerative medicine stem cell harvest and deployment procedure takes less than 2 hours to complete.

At the Clero Stem Cell Treatment Center, we are committed not only to delivering a high degree of quality care for our patients suffering and recovering from stroke, but we are also dedicated to stem cell research and the advancement of regenerative medicine through the investigational use of Adipose Derived Stem Cells (ADSC’s) for clinical research and deployment.





Parkinson’s Disease

Stroke management generally includes control and limitation of swelling, edema, inflammation and neovascularization of damaged tissue. After a few months of therapy and rehabilitation, patients are usually told that further progress is unlikely.

Parkinson’s Disease (PD) is a progressive degenerative disorder of the central nervous system that affects close to one million Americans. PD is a chronic and progressive disorder that is thought to be caused by destruction of the dopamine (an important neurotransmitter) generating brain cells (neurons) in the midbrain. The cause of PD is unknown and there is no cure so treatment is focused on medication and management of symptoms.






As brain cells are destroyed, and dopamine production progressively drops, patients experience characteristic tremors and speech, balance, and motor problems which develop. The primary treatment for Parkinson’s disease, thus far, has been medications that replace or mimic dopamine. Generally, these type of medications do improve symptoms, however, they do not slow disease progression. Additionally, their adverse side effects increase with long-term use. One goal of regenerative medicine’s management of Parkinson’s Disease is to curb the loss of brain cells and slow down (or halt) the symptom progression.

Current research directions include investigations into new animal models of the disease and of the potential usefulness of gene therapy, stem cell transplants and neuro-protective agents. There is hope that mesenchymal stem cells will mitigate the degenerative effects of the advancing Parkinson’s. This is a promising approach, as Medical News Today reports, “Parkinson’s Research Breakthrough, Thanks To Stem Cells From Patient With Rapidly Progressing Disease.” (Paddock, C. (2011, August 23)).





The Clero Stem Cell Treatment Center offers a protocol for Parkinson’s Disease damage that utilizes the beneficial properties of adult stem cells and specially developed specific SVF deployment protocol that attempts to utilize the anti-inflammatory and potential regenerative properties of SVF (rich in mesenchymal stem cells and growth factors).

SVF is systemically deployed and is expected to focus on damaged areas of the central nervous system. Special measures are taken to optimize transport of the SVF across the blood-brain barrier to improve central nervous system uptake. During an outpatient process, the patient’s own stem cells are derived from adipose (fat) tissue – the richest source of adult stem cells–which is harvested by our surgeon during a mini-liposuction under local anesthesia. This regenerative medicine stem cell harvest and deployment procedure takes less than 2 hours to complete.





Cognitive Impairment

The CDC reports that more than 16 million people in the United States are living with cognitive impairment. Age is the greatest risk factor for cognitive impairment, and as the Baby Boomer generation passes age 65, the number of people living with cognitive impairment is expected to jump dramatically. An estimated 5.1 million Americans aged 65 years or older may currently have Alzheimer’s disease, the most well-known form of cognitive impairment; this number may rise to 13.2 million by 2050. Of adults with perceived cognitive impairment in five states (CA, FL, IA, LA, and MI), 34% were under the age of 50; and 66% were aged 50 years or older.

Cognitive impairment is when a person has trouble remembering, learning new things, concentrating, or making decisions that affect their everyday life. Cognitive impairment ranges from mild to severe. With mild impairment, people may begin to notice changes in cognitive functions, but still be able to do their everyday activities. Severe levels of impairment can lead to losing the ability to understand the meaning or importance of something and the ability to talk or write, resulting in the inability to live independently.

Cognitive impairment is caused by degenerative processes in the brain – processes that can in some cases be prevented, retarded, and even reversed.

The Cleo Stem Cell Treatment Center’s regenerative medicine approach to cognitive impairment involves harnessing the beneficial properties of adult stem cells. The patient’s own stem cells are isolated from adipose (fat) tissue, which is removed by liposuction, usually from the abdominal area, by our experienced surgeon. These cells are then concentrated and intravenously infused back into the patient. This outpatient procedure, performed in our fully accredited surgical center, takes less than 2 hours.





Peripheral Neuropathy

Peripheral neuropathy (PN) is a degenerative disorder of the nerves (usually of the hands and feet) and has many causes including traumatic injuries, infections (neuritis), metabolic problems and exposure to toxins.

One of the most common causes of PN is diabetes, and many cases are due to auto-immune disorders, but frequently, the cause of neuropathy cannot be identified.

PN often causes symptoms of numbness and moderate to severe pain described as burning or tingling. Physicians use a number of medications to reduce the painful symptoms of peripheral neuropathy. Some cases progress and are resistant to medical therapy, making it difficult to manage symptoms. There is hope that mesenchymal stem cells will mitigate some of the degenerative effects of neuropathy.

The Clero Stem Cell Treatment Center offers a protocol for PN that utilizes the beneficial properties of adult stem cells. The Clero Stem Cell Treatment Center employs specially developed specific SVF deployment protocol that attempts to utilize the anti-inflammatory and potential regenerative properties of SVF (rich in mesenchymal stem cells and growth factors). SVF is systemically deployed and is expected to focus on damaged areas of the peripheral nervous system. During an outpatient process, the patient’s own stem cells are derived from adipose (fat) tissue – the richest source of adult stem cells–which are harvested by our surgeon during a mini- liposuction under local anesthesia. This regenerative medicine stem cell harvest and deployment procedure takes less than 2 hours to complete.





Multiple Sclerosis

Multiple Sclerosis is a debilitating neurologic disease that is thought to be caused by destruction of the myelin sheaths (fatty protective insulation) around axons of the brain and spinal cord. Loss of myelin impacts the ability of these tissues to conduct signals and the inflammatory process can lead to scarring resulting in a broad range of symptoms. This myelin damage appears to be related primarily to an auto-immune dysfunction, but there also appears to be environmental and genetic factors involved.

There is no known cure for the physical and cognitive defects associated with chronic Multiple Sclerosis. Many investigators are looking at using the regenerative properties of cell therapy to mitigate the impact of Multiple Sclerosis on the nervous system.

The Clero Stem Cell Treatment Center offers a protocol for Multiple Sclerosis that utilizes the beneficial properties of adult stem cells. The Clero Stem Cell Treatment Center employs specially developed specific SVF deployment protocol that attempts to utilize the anti-inflammatory and potential regenerative properties of SVF (rich in mesenchymal stem cells and growth factors). SVF is systemically deployed and is expected to focus on damaged areas of the central and peripheral nervous system.

During an outpatient process, the patient’s own stem cells are derived from adipose (fat) tissue – the richest source of adult stem cells–which are harvested by our surgeon during a mini-liposuction under local anesthesia. This regenerative medicine stem cell harvest and deployment procedure takes less than 2 hours to complete.





Other Neurological Disorders

Neurological disorders encompass a wide range of infirmities of the nervous system. Some are caused by injuries to the spinal cord or brain, or by problems with the brain’s structure or electrical system. Many are progressive degenerative disorders, often with inflammatory components. Examples of these type of neurological disorders include: Amyotrophic lateral sclerosis (ALS), Muscular Dystrophy, Huntington’s disease, Spinal Muscular Atrophy, and Alzheimer’s Dementia. Because these neurological diseases affect the brain, spinal cord, and nerves, they may cause muscle weakness, coordination and movement problems, loss of sensation, confusion, cognitive and mood disturbances, and paralysis. Effective treatments for these conditions are limited at this time, which is why scientists and patients are exploring regenerative medicine – especially stem cell therapy.

The Clero Stem Cell Treatment Center offers various protocols for these type of neurological disorders which are characterized by progressive degeneration and inflammation, that utilizes the beneficial properties of adult stem cells. The Clero Stem Cell Treatment Center employs specially developed specific SVF deployment protocol that attempts to utilize the anti-inflammatory and potential regenerative properties of SVF (rich in mesenchymal stem cells and growth factors). SVF is systemically deployed and is expected to focus on damaged areas of the central and peripheral nervous system. During an outpatient process, the patient’s own stem cells are derived from adipose (fat) tissue – the richest source of adult stem cells–which are harvested by our surgeon during a mini-liposuction under local anesthesia. This regenerative medicine stem cell harvest and deployment procedure takes less than 2 hours to complete. Not all patients with neurological diseases respond to stem cell therapy, and each patient must be assessed individually to determine the potential for optimal results from this regenerative process.

Contact Us

Address

Middle East
Bahrain

Zinj Manama

Doha | Qatar

Boston Medical Center Al Waab street Doha Qatar


USA
Beverly Hills Los Angeles California
Las Vegas Nevada

Dr. Pierre R. Clero MD.

US Number

+1 702 6054502

Bahrain
Faith Ocampo: Patient coordinator:

+973 36197919

DOHA | QATAR

+974 33861017